Telstran Plus Dosage/Direction for Use

Posology: TELSTRAN PLUS should be taken once daily. The dose of telmisartan could be up-titrated before switching to TELSTRAN PLUS. Direct change from monotherapy to the fixed combinations may be considered.
TELSTRAN PLUS 40/12.5 mg may be administered in patients whose blood pressure is not adequately controlled by telmisartan 40 mg or hydrochlorothiazide.
TELSTRAN PLUS 80/12.5 mg may be administered in patients whose blood pressure is not adequately controlled by telmisartan 80 mg or by TELSTRAN PLUS 40/12.5 mg.
TELSTRAN PLUS may be taken with or without food.
The maximum antihypertensive effect is generally attained with TELSTRAN PLUS 4 - 8 weeks after the start of treatment.
When necessary, TELSTRAN PLUS may be administered with another antihypertensive drug.
In patients with severe hypertension treatment with telmisartan at doses up to 160 mg alone and in combination with hydrochlorothiazide 12.5 - 25 mg daily was well tolerated and effective.
Renal impairment: Due to the hydrochlorothiazide component, TELSTRAN PLUS should not be used in patients with severe renal dysfunction (creatinine clearance< 30 ml/min). Loop diuretics are preferred to thiazides in this population. Experience in patients with mild to moderate renal impairment is modest but has not suggested adverse renal effects and dose adjustment is not considered necessary. Periodic monitoring of renal function is advised.
Hepatic Impairment: In patients with mild to moderate hepatic impairment the posology should not exceed TELSTRAN PLUS 40mg/12.5mg once daily. TELSTRAN PLUS is not indicated in patients with severe hepatic impairment. Thiazides should be used with caution in patients with impaired hepatic function.
Elderly: No dose adjustment is necessary.
Children and adolescents: Safety and efficacy of TELSTRAN PLUS have not been established in children and in adolescents up to 18 years.
Route of Administration: TELSTRAN PLUS should be taken orally with liquid, with or without food.
Precautions to be taken before handling or administering the medicinal product.
TELSTRAN PLUS should be kept in the sealed blister due to the hygroscopic property of the tablets. Tablets should be taken out of the blister shortly before administration.